Amyotrophic lateral sclerosis transcriptomics reveals immunological effects of low-dose interleukin-2
نویسندگان
چکیده
منابع مشابه
Transcriptomics in amyotrophic lateral sclerosis.
Amyotrophic lateral sclerosis (ALS) is an adult-onset, incurable neurodegenerative disease characterized by the selective death of upper and lowers motor neurons in the spinal cord, brainstem and motor cortex, which ultimately leads to paralysis and death within 2-3 years of onset. ALS is poorly understood, although multiple studies have been proposed to explain the pathophysiological mechanism...
متن کاملCan Transcriptomics Cut the Gordian Knot of Amyotrophic Lateral Sclerosis?
Amyotrophic lateral sclerosis (ALS) is an adult-onset degenerative disease characterized by the loss of upper and lower motor neurons, progressive muscle atrophy, paralysis and death, which occurs within 2-5 years of diagnosis. Most cases appear sporadically but some are familial, usually inherited in an autosomal dominant pattern. It is postulated that the disease results from the combination ...
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Amyotrophic lateral sclerosis (ALS) is a motor neuron disease characterized by degeneration and loss of upper and lower motor neurons from the motor cortex, brainstem and spinal cord although evidence is suggesting that there is further involvement of other cell types in the surrounding tissue. Transcriptomic analysis by gene expression profiling using microarray technology has enabled the dete...
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Abstract Background: Amyotrophic lateral sclerosis (ALS) is a progressive neurological disorder with high mortality and morbidity. Some risk factors have been implicated for ALS such as exposure to high magnetic fields, and trace elements like selenium, cadmium and lead. Afew studies have been carried out throughout the world to evaluate the prevalence of ALS among veterans. This stud...
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ژورنال
عنوان ژورنال: Brain Communications
سال: 2021
ISSN: 2632-1297
DOI: 10.1093/braincomms/fcab141